Revealing Potential Biomarkers of Functional Dyspepsia by Combining H-1 NMR Metabonomics Techniques and an Integrative Multi-objective Optimization Method

doi:10.1038/srep18852

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	Revealing Potential Biomarkers of Functional Dyspepsia by Combining H-1 NMR Metabonomics Techniques and an Integrative Multi-objective Optimization Method
	Wu, Qiaofeng 1; Zou, Meng 2; Yang, Mingxiao 1; Zhou, Siyuan 1; Yan, Xianzhong 3; Sun, Bo 3; Wang, Yong2 ; Chang, Shyang 4; Tang, Yong 1; Liang, Fanrong 1; Yu, Shuguang 1
	2016-01-08
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	6 页码:10
摘要	Metabonomics methods have gradually become important auxiliary tools for screening disease biomarkers. However, recognition of metabolites or potential biomarkers closely related to either particular clinical symptoms or prognosis has been difficult. The current study aims to identify potential biomarkers of functional dyspepsia (FD) by a new strategy that combined hydrogen nuclear magnetic resonance (H-1 NMR)-based metabonomics techniques and an integrative multi-objective optimization (LPIMO) method. First, clinical symptoms of FD were evaluated using the Nepean Dyspepsia Index (NDI), and plasma metabolic profiles were measured by H-1 NMR. Correlations between the key metabolites and the NDI scores were calculated. Then, LPIMO was developed to identify a multi-biomarker panel by maximizing diagnostic ability and correlation with the NDI score. Finally, a KEGG database search elicited the metabolic pathways in which the potential biomarkers are involved. The results showed that glutamine, alanine, proline, HDL, beta-glucose, alpha-glucose and LDL/VLDL levels were significantly altered in FD patients. Among them, phosphatidycholine (PtdCho) and leucine/isoleucine (Leu/Ile) were positively and negatively correlated with the NDI Symptom Index (NDSI) respectively. Our procedure not only significantly improved the credibility of the biomarkers, but also demonstrated the potential of further explorations and applications to diagnosis and treatment of complex disease.
DOI	10.1038/srep18852
语种	英语
资助项目	National Natural Science Foundation of China[81373737] ; National Natural Science Foundation of China[11422108] ; National Basic Research Program of China[2012CB518501] ; Fok Ying-Tong Education Foundation, China[141041] ; Department of Science and Technology Fund of Sichuan Province[2015JQO058]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000368677000001
出版者	NATURE PUBLISHING GROUP
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/21815
专题	应用数学研究所
通讯作者	Liang, Fanrong; Yu, Shuguang
作者单位	1.Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Coll, Chengdu 610075, Sichuan, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100080, Peoples R China 3.Natl Ctr Biomed Anal, Beijing 100850, Peoples R China 4.Natl Tsing Hua Univ, Dept Elect Engn, Hsinchu 300, Taiwan
推荐引用方式 GB/T 7714	Wu, Qiaofeng,Zou, Meng,Yang, Mingxiao,et al. Revealing Potential Biomarkers of Functional Dyspepsia by Combining H-1 NMR Metabonomics Techniques and an Integrative Multi-objective Optimization Method[J]. SCIENTIFIC REPORTS,2016,6:10.
APA	Wu, Qiaofeng.,Zou, Meng.,Yang, Mingxiao.,Zhou, Siyuan.,Yan, Xianzhong.,...&Yu, Shuguang.(2016).Revealing Potential Biomarkers of Functional Dyspepsia by Combining H-1 NMR Metabonomics Techniques and an Integrative Multi-objective Optimization Method.SCIENTIFIC REPORTS,6,10.
MLA	Wu, Qiaofeng,et al."Revealing Potential Biomarkers of Functional Dyspepsia by Combining H-1 NMR Metabonomics Techniques and an Integrative Multi-objective Optimization Method".SCIENTIFIC REPORTS 6(2016):10.