Tumor characterization and stratification by integrated molecular profiles reveals essential pan-cancer features

doi:10.1186/s12864-015-1687-x

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	Tumor characterization and stratification by integrated molecular profiles reveals essential pan-cancer features
	Liu, Zhaoqi; Zhang, Shihua
	2015-07-07
发表期刊	BMC GENOMICS
ISSN	1471-2164
卷号	16 页码:12
摘要	Background: Identification of tumor heterogeneity and genomic similarities across different cancer types is essential to the design of effective stratified treatments and for the discovery of treatments that can be extended to different types of tumors. However, systematic investigations on comprehensive molecular profiles have not been fully explored to achieve this goal. Results: Here, we performed a network-based integrative pan-cancer genomic analysis on >3000 samples from 12 cancer types to uncover novel stratifications among tumors. Our study not only revealed recurrently reported cross-cancer similarities, but also identified novel ones. The macro-scale stratification demonstrates strong clinical relevance and reveals consistent risk tendency among cancer types. The micro-scale stratification shows essential pan-cancer heterogeneity with subgroup-specific gene network characteristics and biological functions. Conclusions: In summary, our comprehensive network-based pan-cancer stratification provides valuable information about inter- and intra- cancer stratification for patient clinical assessments and therapeutic strategies.
DOI	10.1186/s12864-015-1687-x
语种	英语
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:000357446000001
出版者	BIOMED CENTRAL LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/212
专题	应用数学研究所
通讯作者	Zhang, Shihua
作者单位	Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhaoqi,Zhang, Shihua. Tumor characterization and stratification by integrated molecular profiles reveals essential pan-cancer features[J]. BMC GENOMICS,2015,16:12.
APA	Liu, Zhaoqi,&Zhang, Shihua.(2015).Tumor characterization and stratification by integrated molecular profiles reveals essential pan-cancer features.BMC GENOMICS,16,12.
MLA	Liu, Zhaoqi,et al."Tumor characterization and stratification by integrated molecular profiles reveals essential pan-cancer features".BMC GENOMICS 16(2015):12.