KMS Of Academy of mathematics and systems sciences, CAS
| Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies | |
Zhang, Wei; Li, Qizhai
| |
| 2015-07-15 | |
| Source Publication | SCIENTIFIC REPORTS
 |
| ISSN | 2045-2322 |
| Volume | 5Pages:12 |
| Abstract | The coefficient in a linear regression model is commonly employed to evaluate the genetic effect of a single nucleotide polymorphism associated with a quantitative trait under the assumption that the trait value follows a normal distribution or is appropriately normally distributed after a certain transformation. When this assumption is violated, the distribution-free tests are preferred. In this work, we propose the nonparametric risk (NR) and nonparametric odds (NO), obtain the asymptotic normal distribution of estimated NR and then construct the confidence intervals. We also define the genetic models using NR, construct the test statistic under a given genetic model and a robust test, which are free of the genetic uncertainty. Simulation studies show that the proposed confidence intervals have satisfactory cover probabilities and the proposed test can control the type I error rates and is more powerful than the exiting ones under most of the considered scenarios. Application to gene of PTPN22 and genomic region of 6p21.33 from the Genetic Analysis Workshop 16 for association with the anticyclic citrullinated protein antibody further show their performances. |
| DOI | 10.1038/srep12105 |
| Language | 英语 |
| Funding Project | National Science Foundation of China[11371353] ; National Science Foundation of China[61134013] ; Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences[XDB13040600] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000357915600002 |
| Publisher | NATURE PUBLISHING GROUP |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/20329 |
| Collection | 系统科学研究所 |
| Corresponding Author | Li, Qizhai |
| Affiliation | Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst Control, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Wei,Li, Qizhai. Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies[J]. SCIENTIFIC REPORTS,2015,5:12. |
| APA | Zhang, Wei,&Li, Qizhai.(2015).Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies.SCIENTIFIC REPORTS,5,12. |
| MLA | Zhang, Wei,et al."Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies".SCIENTIFIC REPORTS 5(2015):12. |
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