Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies

doi:10.1038/srep12105

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	Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies
	Zhang, Wei; Li, Qizhai
	2015-07-15
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	5 页码:12
摘要	The coefficient in a linear regression model is commonly employed to evaluate the genetic effect of a single nucleotide polymorphism associated with a quantitative trait under the assumption that the trait value follows a normal distribution or is appropriately normally distributed after a certain transformation. When this assumption is violated, the distribution-free tests are preferred. In this work, we propose the nonparametric risk (NR) and nonparametric odds (NO), obtain the asymptotic normal distribution of estimated NR and then construct the confidence intervals. We also define the genetic models using NR, construct the test statistic under a given genetic model and a robust test, which are free of the genetic uncertainty. Simulation studies show that the proposed confidence intervals have satisfactory cover probabilities and the proposed test can control the type I error rates and is more powerful than the exiting ones under most of the considered scenarios. Application to gene of PTPN22 and genomic region of 6p21.33 from the Genetic Analysis Workshop 16 for association with the anticyclic citrullinated protein antibody further show their performances.
DOI	10.1038/srep12105
语种	英语
资助项目	National Science Foundation of China[11371353] ; National Science Foundation of China[61134013] ; Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences[XDB13040600]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000357915600002
出版者	NATURE PUBLISHING GROUP
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/20329
专题	系统科学研究所
通讯作者	Li, Qizhai
作者单位	Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst Control, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wei,Li, Qizhai. Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies[J]. SCIENTIFIC REPORTS,2015,5:12.
APA	Zhang, Wei,&Li, Qizhai.(2015).Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies.SCIENTIFIC REPORTS,5,12.
MLA	Zhang, Wei,et al."Nonparametric Risk and Nonparametric Odds in Quantitative Genetic Association Studies".SCIENTIFIC REPORTS 5(2015):12.