Colored Noise Induced Bistable Switch in the Genetic Toggle Switch Systems

doi:10.1109/TCBB.2014.2368982

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	Colored Noise Induced Bistable Switch in the Genetic Toggle Switch Systems
	Wang, Pei 1,2; Lu, Jinhu3,4 ; Yu, Xinghuo 2
	2015-05-01
发表期刊	IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
ISSN	1545-5963
卷号	12 期号:3 页码:579-589
摘要	Noise can induce various dynamical behaviors in nonlinear systems. White noise perturbed systems have been extensively investigated during the last decades. In gene networks, experimentally observed extrinsic noise is colored. As an attempt, we investigate the genetic toggle switch systems perturbed by colored extrinsic noise and with kinetic parameters. Compared with white noise perturbed systems, we show there also exists optimal colored noise strength to induce the best stochastic switch behaviors in the single toggle switch, and the best synchronized switching in the networked systems, which demonstrate that noise-induced optimal switch behaviors are widely in existence. Moreover, under a wide range of system parameter regions, we find there exist wider ranges of white and colored noises strengths to induce good switch and synchronization behaviors, respectively; therefore, white noise is beneficial for switch and colored noise is beneficial for population synchronization. Our observations are very robust to extrinsic stimulus strength, cell density, and diffusion rate. Finally, based on the Waddington's epigenetic landscape and the Wiener-Khintchine theorem, physical mechanisms underlying the observations are interpreted. Our investigations can provide guidelines for experimental design, and have potential clinical implications in gene therapy and synthetic biology.
关键词	Colored noise bistable switch bifurcation synchronization quorum sensing
DOI	10.1109/TCBB.2014.2368982
语种	英语
资助项目	National Science and Technology Major Project of China[2014ZX10004-001-014] ; National Natural Science Foundation of China[61304151] ; National Natural Science Foundation of China[11472290] ; National Natural Science Foundation of China[61472027] ; National Natural Science Foundation of China[11105040] ; National Natural Science Foundation of China[61025017] ; Science Foundation of Henan University[2012YBZR007] ; Science Foundation of Henan University[2013YBRW005] ; Australia ARC[DP130104765]
WOS研究方向	Biochemistry & Molecular Biology ; Computer Science ; Mathematics
WOS类目	Biochemical Research Methods ; Computer Science, Interdisciplinary Applications ; Mathematics, Interdisciplinary Applications ; Statistics & Probability
WOS记录号	WOS:000356608100010
出版者	IEEE COMPUTER SOC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/20061
专题	系统科学研究所
通讯作者	Wang, Pei
作者单位	1.Henan Univ, Sch Math & Informat Sci, Kaifeng 475001, Peoples R China 2.RMIT Univ, Sch Elect & Comp Engn, Melbourne, Vic 3001, Australia 3.Chinese Acad Sci, Acad Math & Syst Sci, Inst Syst Sci, Beijing 100080, Peoples R China 4.King Abdulaziz Univ, Fac Engn, Jeddah 21413, Saudi Arabia
推荐引用方式 GB/T 7714	Wang, Pei,Lu, Jinhu,Yu, Xinghuo. Colored Noise Induced Bistable Switch in the Genetic Toggle Switch Systems[J]. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS,2015,12(3):579-589.
APA	Wang, Pei,Lu, Jinhu,&Yu, Xinghuo.(2015).Colored Noise Induced Bistable Switch in the Genetic Toggle Switch Systems.IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS,12(3),579-589.
MLA	Wang, Pei,et al."Colored Noise Induced Bistable Switch in the Genetic Toggle Switch Systems".IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS 12.3(2015):579-589.