Adjustment of basal insulin infusion rate in T1DM by hybrid PSO

doi:10.1007/s00500-014-1378-6

CSpace > 系统科学研究所

	Adjustment of basal insulin infusion rate in T1DM by hybrid PSO
	Lou, Zhijiang 1; Liu, Bo2 ; Xie, Hongzhi 1; Wang, Youqing 1
	2015-07-01
发表期刊	SOFT COMPUTING
ISSN	1432-7643
卷号	19 期号:7 页码:1921-1937
摘要	Basal insulin infusion rate which should be adjusted to increase or decrease insulin delivery with the varying blood sugar level plays a key role in type 1 diabetes mellitus (T1DM) patients for maintaining the blood glucose level approximately steady within reference range in order to avoid the complications developed from diabetes. This paper proposes an effective hybrid particle swarm optimization (HPSO) algorithm for solving the basal insulin infusion rate problem. In HPSO, bad experience lesson learning scheme and local search based on chaotic dynamics are proposed to make a good balance between global exploration and local exploitation. Simulation results based on a set of well-known optimization benchmark instances and the basal insulin infusion rate adjustment problem for T1DM demonstrate the effectiveness of the proposed HPSO. In silico tests on standard virtual subject via HPSO show that under nominal condition the blood glucose concentrations could be kept within a range of 80-150 mg/dL within less than 5 days; meanwhile, in case of random variations in meal timings within 60 min or meal amounts within 75 % deviation from the nominal values, the blood glucose concentrations could be kept within the safe regions.
关键词	Particle swarm optimization (PSO) Glycemic control Basal insulin infusion rate optimization Type 1 diabetes mellitus
DOI	10.1007/s00500-014-1378-6
语种	英语
资助项目	National Natural Science Foundation of China[61374099] ; National Natural Science Foundation of China[71101139] ; Beijing Nova Program[2011025] ; EFSD/CDS/Lilly grant ; Fok Ying-Tong Education Foundation[131060]
WOS研究方向	Computer Science
WOS类目	Computer Science, Artificial Intelligence ; Computer Science, Interdisciplinary Applications
WOS记录号	WOS:000355934500012
出版者	SPRINGER
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/20019
专题	系统科学研究所
通讯作者	Wang, Youqing
作者单位	1.Beijing Univ Chem Technol, Coll Informat Sci & Technol, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Lou, Zhijiang,Liu, Bo,Xie, Hongzhi,et al. Adjustment of basal insulin infusion rate in T1DM by hybrid PSO[J]. SOFT COMPUTING,2015,19(7):1921-1937.
APA	Lou, Zhijiang,Liu, Bo,Xie, Hongzhi,&Wang, Youqing.(2015).Adjustment of basal insulin infusion rate in T1DM by hybrid PSO.SOFT COMPUTING,19(7),1921-1937.
MLA	Lou, Zhijiang,et al."Adjustment of basal insulin infusion rate in T1DM by hybrid PSO".SOFT COMPUTING 19.7(2015):1921-1937.