A measure of discrepancy of multiple sequences

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	A measure of discrepancy of multiple sequences
	Fang, WW ; Roberts, FS ; Ma, ZR
	2001-09-01
发表期刊	INFORMATION SCIENCES
ISSN	0020-0255
卷号	137 期号:1-4 页码:75-102
摘要	Multiple sequence comparison is a basic problem for molecular biology and other sciences. In this paper, we introduce the concept of complete information set and some measurement principles for measuring discrepancy among multiple sequences. Based on them, we present a new measurement method satisfying the principles for comparing multiple sequences. We illustrate that this method can effectively distinguish different random sequences or DNA sequences of length 8000 by comparisons of 6-8 symbol (base) strings or protein sequences of length 8000 by comparisons of 3-4 symbol (amino acid) strings. It can also measure slight changes of a sequence, e.g., insertion or deletion of a symbol (a base or an amino acid) in a sequence. It is applied in the study of molecular evolution, and the elementary result shows a hierarchic relationship among the cytochrome C protein sequences of different species, much as that in taxonomy. (C) 2001 Elsevier Science Inc. All rights reserved.
关键词	multiple sequence comparison entropy DNA information discrepancy
语种	英语
WOS研究方向	Computer Science
WOS类目	Computer Science, Information Systems
WOS记录号	WOS:000170199000006
出版者	ELSEVIER SCIENCE INC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/15974
专题	中国科学院数学与系统科学研究院
通讯作者	Fang, WW
作者单位	1.Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100080, Peoples R China 2.Rutgers State Univ, Ctr Discrete Math, Piscataway, NJ 08855 USA 3.Rutgers State Univ, Theoret Comp Sci Ctr, DIMACS, Piscataway, NJ 08855 USA 4.Rutgers State Univ, Waksman Inst Microbiol, Piscataway, NJ 08855 USA
推荐引用方式 GB/T 7714	Fang, WW,Roberts, FS,Ma, ZR. A measure of discrepancy of multiple sequences[J]. INFORMATION SCIENCES,2001,137(1-4):75-102.
APA	Fang, WW,Roberts, FS,&Ma, ZR.(2001).A measure of discrepancy of multiple sequences.INFORMATION SCIENCES,137(1-4),75-102.
MLA	Fang, WW,et al."A measure of discrepancy of multiple sequences".INFORMATION SCIENCES 137.1-4(2001):75-102.