KMS Of Academy of mathematics and systems sciences, CAS
| Marginal regression models with time-varying coefficients for recurrent event data | |
Sun, Liuquan2 ; Zhou, Xian1; Guo, Shaojun2
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| 2011-08-15 | |
| Source Publication | STATISTICS IN MEDICINE
 |
| ISSN | 0277-6715 |
| Volume | 30Issue:18Pages:2265-2277 |
| Abstract | Recurrent event data arise frequently from medical research. Examples include repeated infections, recurrence of tumors, relapse of leukemia, repeated hospitalizations, recurrence of symptoms of a disease, and so on. In the analysis of recurrent event data, the proportional rates model assumes that the regression coefficients are time invariant. In reality, however, these parameters may vary over time, and the temporal covariate effects on the event process are of great interest. In this article, we formulate a class of semiparametric marginal rates models, which incorporate a mixture of time-varying and time-independent parameters, to analyze recurrent event data. For statistical inference on model parameters, an estimation procedure is developed and asymptotic properties of the proposed estimators are established. In addition, we develop tests for investigating whether or not covariate effects vary with time. The finite-sample behaviors of the proposed methods are examined in simulation studies. An example of application of the proposed methodology is illustrated on a set of data from a clinic study on chronic granulomatous disease. Copyright (C) 2011 John Wiley & Sons, Ltd. |
| Keyword | recurrent event data cumulative regression function marginal rates model model checking semiparametric model time-varying coefficients |
| DOI | 10.1002/sim.4260 |
| Language | 英语 |
| Funding Project | Macquarie University ; National Natural Science Foundation of China[10731010] ; National Natural Science Foundation of China[10971015] ; National Natural Science Foundation of China[10721101] ; National Basic Research Program of China (973 Program)[2007CB814902] ; Key Laboratory of RCSDS, CAS[2008DP173182] |
| WOS Research Area | Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics |
| WOS Subject | Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Medicine, Research & Experimental ; Statistics & Probability |
| WOS ID | WOS:000292740100005 |
| Publisher | WILEY-BLACKWELL |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/13012 |
| Collection | 应用数学研究所 |
| Corresponding Author | Zhou, Xian |
| Affiliation | 1.Macquarie Univ, Dept Actuarial Studies, Sydney, NSW 2109, Australia 2.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Sun, Liuquan,Zhou, Xian,Guo, Shaojun. Marginal regression models with time-varying coefficients for recurrent event data[J]. STATISTICS IN MEDICINE,2011,30(18):2265-2277. |
| APA | Sun, Liuquan,Zhou, Xian,&Guo, Shaojun.(2011).Marginal regression models with time-varying coefficients for recurrent event data.STATISTICS IN MEDICINE,30(18),2265-2277. |
| MLA | Sun, Liuquan,et al."Marginal regression models with time-varying coefficients for recurrent event data".STATISTICS IN MEDICINE 30.18(2011):2265-2277. |
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