Marginal regression models with time-varying coefficients for recurrent event data

doi:10.1002/sim.4260

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	Marginal regression models with time-varying coefficients for recurrent event data
	Sun, Liuquan2 ; Zhou, Xian 1; Guo, Shaojun 2
	2011-08-15
发表期刊	STATISTICS IN MEDICINE
ISSN	0277-6715
卷号	30 期号:18 页码:2265-2277
摘要	Recurrent event data arise frequently from medical research. Examples include repeated infections, recurrence of tumors, relapse of leukemia, repeated hospitalizations, recurrence of symptoms of a disease, and so on. In the analysis of recurrent event data, the proportional rates model assumes that the regression coefficients are time invariant. In reality, however, these parameters may vary over time, and the temporal covariate effects on the event process are of great interest. In this article, we formulate a class of semiparametric marginal rates models, which incorporate a mixture of time-varying and time-independent parameters, to analyze recurrent event data. For statistical inference on model parameters, an estimation procedure is developed and asymptotic properties of the proposed estimators are established. In addition, we develop tests for investigating whether or not covariate effects vary with time. The finite-sample behaviors of the proposed methods are examined in simulation studies. An example of application of the proposed methodology is illustrated on a set of data from a clinic study on chronic granulomatous disease. Copyright (C) 2011 John Wiley & Sons, Ltd.
关键词	recurrent event data cumulative regression function marginal rates model model checking semiparametric model time-varying coefficients
DOI	10.1002/sim.4260
语种	英语
资助项目	Macquarie University ; National Natural Science Foundation of China[10731010] ; National Natural Science Foundation of China[10971015] ; National Natural Science Foundation of China[10721101] ; National Basic Research Program of China (973 Program)[2007CB814902] ; Key Laboratory of RCSDS, CAS[2008DP173182]
WOS研究方向	Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics
WOS类目	Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Medicine, Research & Experimental ; Statistics & Probability
WOS记录号	WOS:000292740100005
出版者	WILEY-BLACKWELL
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/13012
专题	应用数学研究所
通讯作者	Zhou, Xian
作者单位	1.Macquarie Univ, Dept Actuarial Studies, Sydney, NSW 2109, Australia 2.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Sun, Liuquan,Zhou, Xian,Guo, Shaojun. Marginal regression models with time-varying coefficients for recurrent event data[J]. STATISTICS IN MEDICINE,2011,30(18):2265-2277.
APA	Sun, Liuquan,Zhou, Xian,&Guo, Shaojun.(2011).Marginal regression models with time-varying coefficients for recurrent event data.STATISTICS IN MEDICINE,30(18),2265-2277.
MLA	Sun, Liuquan,et al."Marginal regression models with time-varying coefficients for recurrent event data".STATISTICS IN MEDICINE 30.18(2011):2265-2277.