An MSE-reduced estimator for the response proportion in a two-stage clinical trial

doi:10.1002/pst.414

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	An MSE-reduced estimator for the response proportion in a two-stage clinical trial
	Li, Qizhai
	2011-05-01
发表期刊	PHARMACEUTICAL STATISTICS
ISSN	1539-1604
卷号	10 期号:3 页码:277-279
摘要	Two-stage design is very useful in clinical trials for evaluating the validity of a specific treatment regimen. When the second stage is allowed to continue, the method used to estimate the response rate based on the results of both stages is critical for the subsequent design. The often-used sample proportion has an evident upward bias. However, the maximum likelihood estimator or the moment estimator tends to underestimate the response rate. A mean-square error weighted estimator is considered here; its performance is thoroughly investigated via Simon's optimal and minimax designs and Shuster's design. Compared with the sample proportion, the proposed method has a smaller bias, and compared with the maximum likelihood estimator, the proposed method has a smaller mean-square error. Copyright (C) 2010 John Wiley & Sons, Ltd.
关键词	truncated binomial distribution clinical trial MLE mean-square error
DOI	10.1002/pst.414
语种	英语
WOS研究方向	Pharmacology & Pharmacy ; Mathematics
WOS类目	Pharmacology & Pharmacy ; Statistics & Probability
WOS记录号	WOS:000290626600012
出版者	WILEY-BLACKWELL
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/12891
专题	系统科学研究所
通讯作者	Li, Qizhai
作者单位	CAS, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Qizhai. An MSE-reduced estimator for the response proportion in a two-stage clinical trial[J]. PHARMACEUTICAL STATISTICS,2011,10(3):277-279.
APA	Li, Qizhai.(2011).An MSE-reduced estimator for the response proportion in a two-stage clinical trial.PHARMACEUTICAL STATISTICS,10(3),277-279.
MLA	Li, Qizhai."An MSE-reduced estimator for the response proportion in a two-stage clinical trial".PHARMACEUTICAL STATISTICS 10.3(2011):277-279.