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Single-particle reconstruction using L-2-gradient flow
Li, Ming1,2; Xu, Guoliang1; Sorzano, Carlos O. S.3; Sun, Fei2; Bajaj, Chandrajit L.4,5
AbstractIn this paper, we present an iterative algorithm for reconstructing a three-dimensional density function from a set of two dimensional electron microscopy images. By minimizing an energy functional consisting of a fidelity term and a regularization term, an L-2-gradient flow is derived. The flow is integrated by a finite element method in the spatial direction and an explicit Euler scheme in the temporal direction. Our method compares favorably with those of the weighted back projection, Fourier method, algebraic reconstruction technique and simultaneous iterative reconstruction technique. (C) 2011 Elsevier Inc. All rights reserved.
KeywordL-2-gradient flow Reconstruction Electron microscopy Single-particle analysis
Funding ProjectNSFC[60773165] ; NSFC[10990013] ; NSFC[30721003] ; Creative Research Groups of China[11021101] ; Ramon y Cajal ; European Social Fund ; Ministerio de Ciencia e Innovacin ; Chinese Academy of Sciences[KGCX1-YW-13] ; Chinese Academy of Sciences[KSCX2-EW-J-3] ; "973" project[2011CB910301] ; NIH[R01-EB004873] ; NIH[R01-GM074258]
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS IDWOS:000297089000001
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Document Type期刊论文
Corresponding AuthorXu, Guoliang
Affiliation1.Chinese Acad Sci, Acad Math & Syst Sci, LSEC, Inst Computat Math & Sci Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100190, Peoples R China
3.Natl Ctr Biotechnol CSIC, Biocomp Unit, Madrid, Spain
4.Univ Texas Austin, Dept Comp Sci, Austin, TX 78712 USA
5.Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA
Recommended Citation
GB/T 7714
Li, Ming,Xu, Guoliang,Sorzano, Carlos O. S.,et al. Single-particle reconstruction using L-2-gradient flow[J]. JOURNAL OF STRUCTURAL BIOLOGY,2011,176(3):259-267.
APA Li, Ming,Xu, Guoliang,Sorzano, Carlos O. S.,Sun, Fei,&Bajaj, Chandrajit L..(2011).Single-particle reconstruction using L-2-gradient flow.JOURNAL OF STRUCTURAL BIOLOGY,176(3),259-267.
MLA Li, Ming,et al."Single-particle reconstruction using L-2-gradient flow".JOURNAL OF STRUCTURAL BIOLOGY 176.3(2011):259-267.
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