Regression analysis of longitudinal data with time-dependent covariates in the presence of informative observation and censoring times

doi:10.1016/j.jspi.2011.03.013

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	Regression analysis of longitudinal data with time-dependent covariates in the presence of informative observation and censoring times
	Sun, Liuquan1 ; Song, Xinyuan 2; Zhou, Jie 1
	2011-08-01
发表期刊	JOURNAL OF STATISTICAL PLANNING AND INFERENCE
ISSN	0378-3758
卷号	141 期号:8 页码:2902-2919
摘要	In longitudinal observational studies, repeated measures are often correlated with observation times as well as censoring time. This article proposes joint modeling and analysis of longitudinal data with time-dependent covariates in the presence of informative observation and censoring times via a latent variable. Estimating equation approaches are developed for parameter estimation and asymptotic properties of the proposed estimators are established. In addition, a generalization of the semiparametric model with time-varying coefficients for the longitudinal response is considered. Furthermore, a lack-of-fit test is provided for assessing the adequacy of the model, and some tests are presented for investigating whether or not covariate effects vary with time. The finite-sample behavior of the proposed methods is examined in simulation studies, and an application to a bladder cancer study is illustrated. (C) 2011 Elsevier B.V. All rights reserved.
关键词	Generalized estimating equations Informative observation times Joint modeling Latent variables Model checking Time-varying coefficient
DOI	10.1016/j.jspi.2011.03.013
语种	英语
资助项目	National Natural Science Foundation of China[10731010] ; National Natural Science Foundation of China[10971015] ; National Natural Science Foundation of China[11021161] ; National Basic Research Program of China (973 Program)[2007CB814902] ; Key Laboratory of RCSDS, CAS[2008DP173182] ; Hong Kong Special Administration Region[GRF 403109]
WOS研究方向	Mathematics
WOS类目	Statistics & Probability
WOS记录号	WOS:000291067400033
出版者	ELSEVIER SCIENCE BV
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/11574
专题	应用数学研究所
通讯作者	Sun, Liuquan
作者单位	1.Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100190, Peoples R China 2.Chinese Univ Hong Kong, Dept Stat, Hong Kong, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Sun, Liuquan,Song, Xinyuan,Zhou, Jie. Regression analysis of longitudinal data with time-dependent covariates in the presence of informative observation and censoring times[J]. JOURNAL OF STATISTICAL PLANNING AND INFERENCE,2011,141(8):2902-2919.
APA	Sun, Liuquan,Song, Xinyuan,&Zhou, Jie.(2011).Regression analysis of longitudinal data with time-dependent covariates in the presence of informative observation and censoring times.JOURNAL OF STATISTICAL PLANNING AND INFERENCE,141(8),2902-2919.
MLA	Sun, Liuquan,et al."Regression analysis of longitudinal data with time-dependent covariates in the presence of informative observation and censoring times".JOURNAL OF STATISTICAL PLANNING AND INFERENCE 141.8(2011):2902-2919.