KMS Of Academy of mathematics and systems sciences, CAS
| Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2 | |
Yue, Wei-Hua1,2; Wang, Hai-Feng3,4; Sun, Liang-Dan5,6,7; Tang, Fu-Lei1,2; Liu, Zhong-Hua8; Zhang, Hong-Xing9,10; Li, Wen-Qiang9,10; Zhang, Yan-Ling1,2; Zhang, Yang1,2; Ma, Cui-Cui11; Du, Bo12; Wang, Li-Fang1,2; Ren, Yun-Qing5,6,7; Yang, Yong-Feng9,10; Hu, Xiao-Feng1,2; Wang, Yi3,4; Deng, Wei13; Tan, Li-Wen14; Tan, Yun-Long15; Chen, Qi16; Xu, Guang-Ming17; Yang, Gui-Gang15; Zuo, Xian-bo5,6,7; Yan, Hao1,2; Ruan, Yan-Yan1,2; Lu, Tian-Lan1,2; Han, Xue14; Ma, Xiao-Hong13; Wang, Yan1,2; Cai, Li-Wei1,2; Jin, Chao11; Zhang, Hong-Yan1,2; Yan, Jun1,2; Mi, Wei-Feng1,2; Yin, Xian-Yong5,6,7; Ma, Wen-Bin11; Liu, Qi1,2; Kang, Lan1,2; Sun, Wei1,2; Pan, Cheng-Ying1,2; Shuang, Mei1,2; Yang, Fu-De15; Wang, Chuan-Yue16; Yang, Jian-Li17; Li, Ke-Qing12; Ma, Xin16; Li, Ling-Jiang14; Yu, Xin1,2; Li, Qi-Zhai18 ; Huang, Xun8; Lv, Lu-Xian9,10; Li, Tao13; Zhao, Guo-Ping3; Huang, Wei3,4; Zhang, Xue-Jun5,6,7; Zhang, Dai1,2
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| 2011-12-01 | |
| Source Publication | NATURE GENETICS
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| ISSN | 1061-4036 |
| Volume | 43Issue:12Pages:1228-U84 |
| Abstract | To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P(combined) = 4.76 x 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P(combined) = 6.91 x 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P(combined) = 5.14 x 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5' UTR of TSPAN18, P(combined) = 1.09 x 10(-11), OR = 1.29; rs11038172, P(combined) = 7.21 x 10(-10), OR = 1.25; rs835784, P(combined) = 2.73 x 10(-11), OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia. |
| DOI | 10.1038/ng.979 |
| Language | 英语 |
| Funding Project | National High-Tech Research and Development Program of China[2009AA022702] ; National Natural Science Foundation of China[30530290] ; National Natural Science Foundation of China[30870896] ; National Natural Science Foundation of China[81071087] ; National Natural Science Foundation of China[81071088] ; National Basic Research Program of China[2007CB512301] ; National Basic Research Program of China[2011CB707805] ; International Science & Technology Cooperation Program of China[2010DFB30820] |
| WOS Research Area | Genetics & Heredity |
| WOS Subject | Genetics & Heredity |
| WOS ID | WOS:000297931400017 |
| Publisher | NATURE PUBLISHING GROUP |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/11436 |
| Collection | 系统科学研究所 |
| Corresponding Author | Zhang, Dai |
| Affiliation | 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China 2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China 3.Chinese Natl Human Genome Ctr Shanghai, Shanghai Minist Sci & Technol China, Key Lab Hlth & Dis Genom, Shanghai, Peoples R China 4.Shanghai Jiao Tong Univ, State Key Lab Med Genom, Ruijin Hosp, Shanghai 200030, Peoples R China 5.Anhui Med Univ, Inst Dermatol, Hosp 1, Hefei, Peoples R China 6.Anhui Med Univ, Dept Dermatol, Hosp 1, Hefei, Peoples R China 7.Minist Sci & Technol, State Key Lab Dermatol, Hefei, Peoples R China 8.Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China 9.Xinxiang Med Univ, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Peoples R China 10.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China 11.Jinzhou Kangning Hosp, Jinzhou, Peoples R China 12.Hebei Mental Hlth Ctr, Baoding, Peoples R China 13.Sichuan Univ, Dept Psychiat, W China Hosp, Chengdu 610064, Peoples R China 14.Cent S Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha, Peoples R China 15.Beijing Huilongguan Hosp, Beijing, Peoples R China 16.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China 17.Tianjin Municipal, Tianjin Anding Hosp, Tianjin, Peoples R China 18.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Yue, Wei-Hua,Wang, Hai-Feng,Sun, Liang-Dan,et al. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2[J]. NATURE GENETICS,2011,43(12):1228-U84. |
| APA | Yue, Wei-Hua.,Wang, Hai-Feng.,Sun, Liang-Dan.,Tang, Fu-Lei.,Liu, Zhong-Hua.,...&Zhang, Dai.(2011).Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.NATURE GENETICS,43(12),1228-U84. |
| MLA | Yue, Wei-Hua,et al."Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2".NATURE GENETICS 43.12(2011):1228-U84. |
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