Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

doi:10.1038/ng.979

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	Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2
	Yue, Wei-Hua 1,2; Wang, Hai-Feng 3,4; Sun, Liang-Dan 5,6,7; Tang, Fu-Lei 1,2; Liu, Zhong-Hua 8; Zhang, Hong-Xing 9,10; Li, Wen-Qiang 9,10; Zhang, Yan-Ling 1,2; Zhang, Yang 1,2; Ma, Cui-Cui 11; Du, Bo 12; Wang, Li-Fang 1,2; Ren, Yun-Qing 5,6,7; Yang, Yong-Feng 9,10; Hu, Xiao-Feng 1,2; Wang, Yi 3,4; Deng, Wei 13; Tan, Li-Wen 14; Tan, Yun-Long 15; Chen, Qi 16; Xu, Guang-Ming 17; Yang, Gui-Gang 15; Zuo, Xian-bo 5,6,7; Yan, Hao 1,2; Ruan, Yan-Yan 1,2; Lu, Tian-Lan 1,2; Han, Xue 14; Ma, Xiao-Hong 13; Wang, Yan 1,2; Cai, Li-Wei 1,2; Jin, Chao 11; Zhang, Hong-Yan 1,2; Yan, Jun 1,2; Mi, Wei-Feng 1,2; Yin, Xian-Yong 5,6,7; Ma, Wen-Bin 11; Liu, Qi 1,2; Kang, Lan 1,2; Sun, Wei 1,2; Pan, Cheng-Ying 1,2; Shuang, Mei 1,2; Yang, Fu-De 15; Wang, Chuan-Yue 16; Yang, Jian-Li 17; Li, Ke-Qing 12; Ma, Xin 16; Li, Ling-Jiang 14; Yu, Xin 1,2; Li, Qi-Zhai18 ; Huang, Xun 8; Lv, Lu-Xian 9,10; Li, Tao 13; Zhao, Guo-Ping 3; Huang, Wei 3,4; Zhang, Xue-Jun 5,6,7; Zhang, Dai 1,2
	2011-12-01
发表期刊	NATURE GENETICS
ISSN	1061-4036
卷号	43 期号:12 页码:1228-U84
摘要	To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P(combined) = 4.76 x 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P(combined) = 6.91 x 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P(combined) = 5.14 x 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5' UTR of TSPAN18, P(combined) = 1.09 x 10(-11), OR = 1.29; rs11038172, P(combined) = 7.21 x 10(-10), OR = 1.25; rs835784, P(combined) = 2.73 x 10(-11), OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.
DOI	10.1038/ng.979
语种	英语
资助项目	National High-Tech Research and Development Program of China[2009AA022702] ; National Natural Science Foundation of China[30530290] ; National Natural Science Foundation of China[30870896] ; National Natural Science Foundation of China[81071087] ; National Natural Science Foundation of China[81071088] ; National Basic Research Program of China[2007CB512301] ; National Basic Research Program of China[2011CB707805] ; International Science & Technology Cooperation Program of China[2010DFB30820]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000297931400017
出版者	NATURE PUBLISHING GROUP
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/11436
专题	系统科学研究所
通讯作者	Zhang, Dai
作者单位	1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China 2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China 3.Chinese Natl Human Genome Ctr Shanghai, Shanghai Minist Sci & Technol China, Key Lab Hlth & Dis Genom, Shanghai, Peoples R China 4.Shanghai Jiao Tong Univ, State Key Lab Med Genom, Ruijin Hosp, Shanghai 200030, Peoples R China 5.Anhui Med Univ, Inst Dermatol, Hosp 1, Hefei, Peoples R China 6.Anhui Med Univ, Dept Dermatol, Hosp 1, Hefei, Peoples R China 7.Minist Sci & Technol, State Key Lab Dermatol, Hefei, Peoples R China 8.Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China 9.Xinxiang Med Univ, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Peoples R China 10.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China 11.Jinzhou Kangning Hosp, Jinzhou, Peoples R China 12.Hebei Mental Hlth Ctr, Baoding, Peoples R China 13.Sichuan Univ, Dept Psychiat, W China Hosp, Chengdu 610064, Peoples R China 14.Cent S Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha, Peoples R China 15.Beijing Huilongguan Hosp, Beijing, Peoples R China 16.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China 17.Tianjin Municipal, Tianjin Anding Hosp, Tianjin, Peoples R China 18.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yue, Wei-Hua,Wang, Hai-Feng,Sun, Liang-Dan,et al. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2[J]. NATURE GENETICS,2011,43(12):1228-U84.
APA	Yue, Wei-Hua.,Wang, Hai-Feng.,Sun, Liang-Dan.,Tang, Fu-Lei.,Liu, Zhong-Hua.,...&Zhang, Dai.(2011).Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.NATURE GENETICS,43(12),1228-U84.
MLA	Yue, Wei-Hua,et al."Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2".NATURE GENETICS 43.12(2011):1228-U84.