Bayes factors in the presence of population stratification

doi:10.1016/j.spl.2011.02.020

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	Bayes factors in the presence of population stratification
	Wang, Linglu 2; Li, Qizhai3 ; Li, Zhaohai 2; Zheng, Gang 1
	2011-07-01
发表期刊	STATISTICS & PROBABILITY LETTERS
ISSN	0167-7152
卷号	81 期号:7 页码:836-841
摘要	Hidden population stratification (PS) is a main concern in the analysis of case-control genetic association studies. All methods to correct for hidden PS have been focused on classical hypothesis testing, and cannot be directly applied to Bayesian analysis. In this paper, to study the impact and the correction of hidden PS on Bayes factor (BF), we use a simple approximation of BF in terms of the maximum likelihood estimates of the odds ratio (OR) and its asymptotic variance. One advantage is that the commonly used principal components analysis method with a large panel of null markers scanned from existing genome-wide association studies can be directly employed to correct for hidden PS in estimating the OR and its asymptotic variance, through which a correction to BF for hidden PS can be achieved. Using simulations, we examine the impact of ignoring hidden PS on BF and show that the proposed method yields an appropriate correction in Bayesian analysis. Published by Elsevier B.V.
关键词	Approximate Bayes factor Clustering Genome-wide association studies Odds ratio Population stratification
DOI	10.1016/j.spl.2011.02.020
语种	英语
资助项目	National Young Science Foundation of China[10901155]
WOS研究方向	Mathematics
WOS类目	Statistics & Probability
WOS记录号	WOS:000291175200017
出版者	ELSEVIER SCIENCE BV
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/11260
专题	系统科学研究所
通讯作者	Zheng, Gang
作者单位	1.NHLBI, Off Biostat Res, Bethesda, MD 20892 USA 2.George Washington Univ, Dept Stat, Washington, DC 20052 USA 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Linglu,Li, Qizhai,Li, Zhaohai,et al. Bayes factors in the presence of population stratification[J]. STATISTICS & PROBABILITY LETTERS,2011,81(7):836-841.
APA	Wang, Linglu,Li, Qizhai,Li, Zhaohai,&Zheng, Gang.(2011).Bayes factors in the presence of population stratification.STATISTICS & PROBABILITY LETTERS,81(7),836-841.
MLA	Wang, Linglu,et al."Bayes factors in the presence of population stratification".STATISTICS & PROBABILITY LETTERS 81.7(2011):836-841.