Reverse engineering large-scale genetic networks: synthetic versus real data

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	Reverse engineering large-scale genetic networks: synthetic versus real data
	Zhang, Luwen 1,2; Xiao, Mei 1,2; Wang, Yong3 ; Zhang, Wu 1
	2010-04-01
发表期刊	JOURNAL OF GENETICS
ISSN	0022-1333
卷号	89 期号:1 页码:73-80
摘要	Development of microarray technology has resulted in an exponential rise in gene expression data. Linear computational methods are of great assistance in identifying molecular interactions, and elucidating the functional properties of gene networks. It overcomes the weaknesses of in vivo experiments including high cost, large noise, and unrepeatable process. In this paper, we propose an easily applied system, Stepwise Network Inference (SWNI), which integrates deterministic linear model with statistical analysis, and has been tested effectively on both simulated experiments and real gene expression data sets. The study illustrates that connections of gene networks can be significantly detected via SWNI with high confidence, when single gene perturbation experiments are performed complying with the algorithm requirements. In particular, our algorithm shows efficiency and outperforms the existing ones presented in this paper when dealing with large-scale sparse networks without any prior knowledge.
关键词	gene regulatory network single gene perturbation linear model stepwise simulated network
语种	英语
资助项目	Shanghai Leading Academic Discipline Project[J50103]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000277769500009
出版者	INDIAN ACAD SCIENCES
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/10954
专题	应用数学研究所
通讯作者	Zhang, Wu
作者单位	1.Shanghai Univ, Sch Comp Engn & Sci, Shanghai 200072, Peoples R China 2.Shanghai Univ, Inst Syst Biol, Shanghai 200072, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Luwen,Xiao, Mei,Wang, Yong,et al. Reverse engineering large-scale genetic networks: synthetic versus real data[J]. JOURNAL OF GENETICS,2010,89(1):73-80.
APA	Zhang, Luwen,Xiao, Mei,Wang, Yong,&Zhang, Wu.(2010).Reverse engineering large-scale genetic networks: synthetic versus real data.JOURNAL OF GENETICS,89(1),73-80.
MLA	Zhang, Luwen,et al."Reverse engineering large-scale genetic networks: synthetic versus real data".JOURNAL OF GENETICS 89.1(2010):73-80.