Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone-Binding Globulin

doi:10.1158/1055-9965.EPI-10-0101

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	Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone-Binding Globulin
	Chu, Lisa W.1,2; Meyer, Tamra E.1; Li, Qizhai3 ; Menashe, Idan 1; Yu, Kai 1; Rosenberg, Philip S.1; Huang, Wen-Yi 1; Quraishi, Sabah M.1; Kaaks, Rudolf 4; Weiss, Jocelyn M.1; Hayes, Richard B.1; Chanock, Stephen J.1; Hsing, Ann W.1
	2010-07-01
发表期刊	CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
ISSN	1055-9965
卷号	19 期号:7 页码:1848-1854
摘要	Background: Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder. Methods: To investigate their biological basis, we examined the possible association between 164 single nucleotide polymorphisms (SNPs) in the 8q24 risk regions spanning 128,101,433-128,828,043 bp, and serum androgen (testosterone, androstenedione, 3 alpha diol G, and bioavailable testosterone), and sex hormone-binding globulin levels in 563 healthy, non-Hispanic, Caucasian men (55-74 years old) from a prospective cohort study (the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial). Age-adjusted linear regression models were used to determine the association between the SNPs in an additive genetic model and log-transformed biomarker levels. Results: Three adjacent SNPs centromeric to prostate cancer risk-region 2 (rs12334903, rs1456310, and rs980171) were associated with testosterone (P < 1.1 x 10(-3)) and bioavailable testosterone (P < 6.3 x 10(-4)). Suggestive associations were seen for a cluster of nine SNPs in prostate cancer risk region 1 and androstenedione (P < 0.05). Conclusions: These preliminary findings require confirmation in larger studies but raise the intriguing hypothesis that genetic variations in the 8q24 cancer risk regions might correlate with androgen levels. Impact: These results might provide some clues for the strong link between 8q24 and prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 19(7); 1848-54. (C) 2010 AACR.
DOI	10.1158/1055-9965.EPI-10-0101
语种	英语
资助项目	Division of Cancer Epidemiology and Genetics ; Division of Cancer Prevention, National Cancer Institute, NIH, Department of Health and Human Services
WOS研究方向	Oncology ; Public, Environmental & Occupational Health
WOS类目	Oncology ; Public, Environmental & Occupational Health
WOS记录号	WOS:000279590100021
出版者	AMER ASSOC CANCER RESEARCH
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/10494
专题	系统科学研究所
通讯作者	Hsing, Ann W.
作者单位	1.NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA 2.NCI, Canc Prevent Fellowship Program, Off Prevent Oncol, NIH, Bethesda, MD 20892 USA 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 4.German Natl Canc Ctr, Div Canc Epidemiol, Heidelberg, Germany
推荐引用方式 GB/T 7714	Chu, Lisa W.,Meyer, Tamra E.,Li, Qizhai,et al. Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone-Binding Globulin[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2010,19(7):1848-1854.
APA	Chu, Lisa W..,Meyer, Tamra E..,Li, Qizhai.,Menashe, Idan.,Yu, Kai.,...&Hsing, Ann W..(2010).Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone-Binding Globulin.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,19(7),1848-1854.
MLA	Chu, Lisa W.,et al."Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone-Binding Globulin".CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 19.7(2010):1848-1854.