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Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone-Binding Globulin
Chu, Lisa W.1,2; Meyer, Tamra E.1; Li, Qizhai3; Menashe, Idan1; Yu, Kai1; Rosenberg, Philip S.1; Huang, Wen-Yi1; Quraishi, Sabah M.1; Kaaks, Rudolf4; Weiss, Jocelyn M.1; Hayes, Richard B.1; Chanock, Stephen J.1; Hsing, Ann W.1
2010-07-01
Source PublicationCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
ISSN1055-9965
Volume19Issue:7Pages:1848-1854
AbstractBackground: Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder. Methods: To investigate their biological basis, we examined the possible association between 164 single nucleotide polymorphisms (SNPs) in the 8q24 risk regions spanning 128,101,433-128,828,043 bp, and serum androgen (testosterone, androstenedione, 3 alpha diol G, and bioavailable testosterone), and sex hormone-binding globulin levels in 563 healthy, non-Hispanic, Caucasian men (55-74 years old) from a prospective cohort study (the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial). Age-adjusted linear regression models were used to determine the association between the SNPs in an additive genetic model and log-transformed biomarker levels. Results: Three adjacent SNPs centromeric to prostate cancer risk-region 2 (rs12334903, rs1456310, and rs980171) were associated with testosterone (P < 1.1 x 10(-3)) and bioavailable testosterone (P < 6.3 x 10(-4)). Suggestive associations were seen for a cluster of nine SNPs in prostate cancer risk region 1 and androstenedione (P < 0.05). Conclusions: These preliminary findings require confirmation in larger studies but raise the intriguing hypothesis that genetic variations in the 8q24 cancer risk regions might correlate with androgen levels. Impact: These results might provide some clues for the strong link between 8q24 and prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 19(7); 1848-54. (C) 2010 AACR.
DOI10.1158/1055-9965.EPI-10-0101
Language英语
Funding ProjectDivision of Cancer Epidemiology and Genetics ; Division of Cancer Prevention, National Cancer Institute, NIH, Department of Health and Human Services
WOS Research AreaOncology ; Public, Environmental & Occupational Health
WOS SubjectOncology ; Public, Environmental & Occupational Health
WOS IDWOS:000279590100021
PublisherAMER ASSOC CANCER RESEARCH
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Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/10494
Collection系统科学研究所
Corresponding AuthorHsing, Ann W.
Affiliation1.NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
2.NCI, Canc Prevent Fellowship Program, Off Prevent Oncol, NIH, Bethesda, MD 20892 USA
3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
4.German Natl Canc Ctr, Div Canc Epidemiol, Heidelberg, Germany
Recommended Citation
GB/T 7714
Chu, Lisa W.,Meyer, Tamra E.,Li, Qizhai,et al. Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone-Binding Globulin[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2010,19(7):1848-1854.
APA Chu, Lisa W..,Meyer, Tamra E..,Li, Qizhai.,Menashe, Idan.,Yu, Kai.,...&Hsing, Ann W..(2010).Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone-Binding Globulin.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,19(7),1848-1854.
MLA Chu, Lisa W.,et al."Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone-Binding Globulin".CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 19.7(2010):1848-1854.
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