Genome-wide association study of circulating vitamin D levels

doi:10.1093/hmg/ddq155

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	Genome-wide association study of circulating vitamin D levels
	Ahn, Jiyoung 2; Yu, Kai ; Stolzenberg-Solomon, Rachael ; Simon, K. Claire 3; McCullough, Marjorie L.6; Gallicchio, Lisa 7; Jacobs, Eric J.6; Ascherio, Alberto 3,4,8,9; Helzlsouer, Kathy 7; Jacobs, Kevin B.; Li, Qizhai10 ; Weinstein, Stephanie J.; Purdue, Mark ; Virtamo, Jarmo 11; Horst, Ronald 12; Wheeler, William 13; Chanock, Stephen ; Hunter, David J.3,4,5; Hayes, Richard B.2; Kraft, Peter 4,5; Albanes, Demetrius 1
	2010-07-01
发表期刊	HUMAN MOLECULAR GENETICS
ISSN	0964-6906
卷号	19 期号:13 页码:2739-2745
摘要	The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer. In a genome-wide association study (GWAS) of 4501 persons of European ancestry drawn from five cohorts, we identified single-nucleotide polymorphisms (SNPs) in the gene encoding group-specific component (vitamin D binding) protein, GC, on chromosome 4q12-13 that were associated with 25(OH) D concentrations: rs2282679 (P = 2.0 x 10(-30)), in linkage disequilibrium (LD) with rs7041, a non-synonymous SNP (D432E; P = 4.1 x 10(-22)) and rs1155563 (P = 3.8 x 10(-25)). Suggestive signals for association with 25(OH) D were also observed for SNPs in or near three other genes involved in vitamin D synthesis or activation: rs3829251 on chromosome 11q13.4 in NADSYN1 [encoding nicotinamide adenine dinucleotide (NAD) synthetase; P = 8.8 x 10(-7)], which was in high LD with rs1790349, located in DHCR7, the gene encoding 7-dehydrocholesterol reductase that synthesizes cholesterol from 7-dehydrocholesterol; rs6599638 in the region harboring the open-reading frame 88 (C10orf88) on chromosome 10q26.13 in the vicinity of ACADSB (acyl-Coenzyme A dehydrogenase), involved in cholesterol and vitamin D synthesis (P = 3.3 x 10(-7)); and rs2060793 on chromosome 11p15.2 in CYP2R1 (cytochrome P450, family 2, subfamily R, polypeptide 1, encoding a key C-25 hydroxylase that converts vitamin D(3) to an active vitamin D receptor ligand; P = 1.4 x 10(-5)). We genotyped SNPs in these four regions in 2221 additional samples and confirmed strong genome-wide significant associations with 25(OH) D through meta-analysis with the GWAS data for GC (P = 1.8 x 10(-49)), NADSYN1/DHCR7 (P = 3.4 x 10(-9)) and CYP2R1 (P = 2.9 x 10(-17)), but not C10orf88 (P = 2.4 x 10(-5)).
DOI	10.1093/hmg/ddq155
语种	英语
资助项目	National Cancer Institute, NIH[N01-CO-12400] ; US Public Health Service[N01-CN-45165] ; US Public Health Service[N01-RC45035] ; US Public Health Service[N01-RC-37004] ; National Cancer Institute, NIH, DHHS[HHSN261201000006C] ; Division of Cancer Epidemiology and Genetics ; Division of Cancer Prevention ; National Cancer Institute (NCI) ; US National Institutes of Health (NIH) ; Department of Health and Human Services (DHHS) ; NIH[P01CA087969] ; NIH[5U01HG004399-2] ; NIH[P01CA055075] ; NIH Kirschstein-NRSA[T32 ES016645-01] ; [U01 CA098710]
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号	WOS:000279674200018
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/10458
专题	系统科学研究所
通讯作者	Albanes, Demetrius
作者单位	1.NCI, Div Canc Epidemiol & Genet, EPS 320, NIH, Bethesda, MD 20892 USA 2.NYU, Sch Med, Dept Environm Med, Div Epidemiol, New York, NY 10016 USA 3.Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA 4.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA 5.Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, Boston, MA 02115 USA 6.Amer Canc Soc, Dept Epidemiol, Atlanta, GA 30303 USA 7.Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD 21202 USA 8.Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA 9.Harvard Univ, Sch Med, Boston, MA USA 10.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China 11.Natl Inst Hlth & Welf, Dept Chron Dis Prevent, FI-00271 Helsinki, Finland 12.Heartland Assays Inc, Ames, IA USA 13.Informat Management Serv Inc, Rockville, MD USA
推荐引用方式 GB/T 7714	Ahn, Jiyoung,Yu, Kai,Stolzenberg-Solomon, Rachael,et al. Genome-wide association study of circulating vitamin D levels[J]. HUMAN MOLECULAR GENETICS,2010,19(13):2739-2745.
APA	Ahn, Jiyoung.,Yu, Kai.,Stolzenberg-Solomon, Rachael.,Simon, K. Claire.,McCullough, Marjorie L..,...&Albanes, Demetrius.(2010).Genome-wide association study of circulating vitamin D levels.HUMAN MOLECULAR GENETICS,19(13),2739-2745.
MLA	Ahn, Jiyoung,et al."Genome-wide association study of circulating vitamin D levels".HUMAN MOLECULAR GENETICS 19.13(2010):2739-2745.