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Disease category-specific annotation of variants using an ensemble learning framework 期刊论文
BRIEFINGS IN BIOINFORMATICS, 2022, 卷号: 23, 期号: 1, 页码: 15
作者:  Cao, Zhen;  Huang, Yanting;  Duan, Ran;  Jin, Peng;  Qin, Zhaohui S.;  Zhang, Shihua
收藏  |  浏览/下载：108/0  |  提交时间：2022/06/21
complex disease  disease category  functional annotation  non-coding variant  ensemble learning  
Joint reconstruction of cis-regulatory interaction networks across multiple tissues using single-cell chromatin accessibility data 期刊论文
BRIEFINGS IN BIOINFORMATICS, 2021, 卷号: 22, 期号: 3, 页码: 15
作者:  Dong, Kangning;  Zhang, Shihua
收藏  |  浏览/下载：111/0  |  提交时间：2022/04/02
cis-regulatory interaction networks  single-cell ATAC-seq  Gaussian graphical LASSO  
Model-based understanding of single-cell CRISPR screening 期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 11
作者:  Duan, Bin;  Zhou, Chi;  Zhu, Chengyu;  Yu, Yifei;  Li, Gaoyang;  Zhang, Shihua;  Zhang, Chao;  Ye, Xiangyun;  Ma, Hanhui;  Qu, Shen;  Zhang, Zhiyuan;  Wang, Ping;  Sun, Shuyang;  Liu, Qi
收藏  |  浏览/下载：185/0  |  提交时间：2020/01/10
Reveal cell type-specific regulatory elements and their characterized histone code classes via a hidden Markov model 期刊论文
BMC GENOMICS, 2018, 卷号: 19, 页码: 13
作者:  Wang, Can;  Zhang, Shihua
收藏  |  浏览/下载：244/0  |  提交时间：2019/01/11
Epigenomics  Cell type-specific regulatory elements  Hidden Markov model  Histone modification  
Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types 期刊论文
BRIEFINGS IN FUNCTIONAL GENOMICS, 2016, 卷号: 15, 期号: 6, 页码: 399-407
作者:  Yang, Xiaofei;  Shao, Xiaojian;  Gao, Lin;  Zhang, Shihua
收藏  |  浏览/下载：156/0  |  提交时间：2018/07/30
DNA methylation patterns  differentially methylation regions  comparative studies  tissue-specific methylation  cancer epigenomics  
Integrative analysis for identifying joint modular patterns of gene-expression and drug-response data 期刊论文
BIOINFORMATICS, 2016, 卷号: 32, 期号: 11, 页码: 1724-1732
作者:  Chen, Jinyu;  Zhang, Shihua
收藏  |  浏览/下载：138/0  |  提交时间：2018/07/30
Systematic DNA methylation analysis of multiple cell lines reveals common and specific patterns within and across tissues of origin 期刊论文
HUMAN MOLECULAR GENETICS, 2015, 卷号: 24, 期号: 15, 页码: 4374-4384
作者:  Yang, Xiaofei;  Shao, Xiaojian;  Gao, Lin;  Zhang, Shihua
收藏  |  浏览/下载：152/0  |  提交时间：2018/07/30
IIIDB: a database for isoform-isoform interactions and isoform network modules 期刊论文
BMC Genomics, 2015, 卷号: 16, 期号: Suppl 2
作者:  Tseng,Yu-Ting;  Li,Wenyuan;  Chen,Ching-Hsien;  Zhang,Shihua;  Chen,Jeremy JW;  Zhou,Xianghong Jasmine;  Liu,Chun-Chi
收藏  |  浏览/下载：139/0  |  提交时间：2018/07/30
Identification of mutated core cancer modules by integrating somatic mutation, copy number variation, and gene expression data 期刊论文
BMC Systems Biology, 2013, 卷号: 7, 期号: Suppl 2
作者:  Zhang,Junhua;  Zhang,Shihua;  Wang,Yong;  Zhang,Xiang-Sun
收藏  |  浏览/下载：138/0  |  提交时间：2018/07/30
A novel computational framework for simultaneous integration of multiple types of genomic data to identify microRNA-gene regulatory modules 期刊论文
BIOINFORMATICS, 2011, 卷号: 27, 期号: 13, 页码: I401-I409
作者:  Zhang, Shihua;  Li, Qingjiao;  Liu, Juan;  Zhou, Xianghong Jasmine
收藏  |  浏览/下载：146/0  |  提交时间：2018/07/30