KMS Of Academy of mathematics and systems sciences, CAS
| High-dimensional genomic data bias correction and data integration using MANCIE | |
Zang, Chongzhi1,2,3; Wang, Tao4,5; Deng, Ke6; Li, Bo1,2,3,7; Hu, Sheng'en8; Qin, Qian8; Xiao, Tengfei1,2,3,9,10; Zhang, Shihua11 ; Meyer, Clifford A.1,2,3; He, Housheng Hansen1,2,3,9,10,12; Brown, Myles3,9,10; Liu, Jun S.7; Xie, Yang4,13,14; Liu, X. Shirley1,2,3
| |
| 2016-04-01 | |
| 发表期刊 | NATURE COMMUNICATIONS
 |
| ISSN | 2041-1723 |
| 卷号 | 7页码:8 |
| 摘要 | High-dimensional genomic data analysis is challenging due to noises and biases in high-throughput experiments. We present a computational method matrix analysis and normalization by concordant information enhancement (MANCIE) for bias correction and data integration of distinct genomic profiles on the same samples. MANCIE uses a Bayesian-supported principal component analysis-based approach to adjust the data so as to achieve better consistency between sample-wise distances in the different profiles. MANCIE can improve tissue-specific clustering in ENCODE data, prognostic prediction in Molecular Taxonomy of Breast Cancer International Consortium and The Cancer Genome Atlas data, copy number and expression agreement in Cancer Cell Line Encyclopedia data, and has broad applications in cross-platform, high-dimensional data integration. |
| DOI | 10.1038/ncomms11305 |
| 语种 | 英语 |
| 资助项目 | US National Institutes of Health (NIH)[U41HG7000] ; US National Institutes of Health (NIH)[1R01GM099409] ; US National Institutes of Health (NIH)[5R01CA172211] ; US National Institutes of Health (NIH)[1R01CA152301] ; National Natural Science Foundation of China (NSFC)[11401338] ; National Natural Science Foundation of China (NSFC)[61422309] ; Leukemia and Lymphoma Society (LLS) |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000374062000001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.amss.ac.cn/handle/2S8OKBNM/22514 |
| 专题 | 应用数学研究所 |
| 通讯作者 | Xie, Yang; Liu, X. Shirley |
| 作者单位 | 1.Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02215 USA 2.Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA 02215 USA 3.Dana Farber Canc Inst, Ctr Funct Canc Epigenet, Boston, MA 02215 USA 4.Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Quantitat Biomed Res Ctr, Dallas, TX 75390 USA 5.Univ Texas SW Med Ctr Dallas, Ctr Genet Host Def, Dallas, TX 75390 USA 6.Tsinghua Univ, Ctr Stat Sci, Beijing 100084, Peoples R China 7.Harvard Univ, Dept Stat, Cambridge, MA 02138 USA 8.Tongji Univ, Sch Life Sci, Dept Bioinformat, Shanghai 200092, Peoples R China 9.Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA 10.Harvard Univ, Sch Med, Boston, MA 02215 USA 11.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China 12.Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada 13.Univ Texas SW Med Ctr Dallas, Dept Bioinformat, Dallas, TX 75390 USA 14.Univ Texas SW Med Ctr Dallas, Simons Comprehens Canc Ctr, Dallas, TX 75390 USA |
| 推荐引用方式 GB/T 7714 | Zang, Chongzhi,Wang, Tao,Deng, Ke,et al. High-dimensional genomic data bias correction and data integration using MANCIE[J]. NATURE COMMUNICATIONS,2016,7:8. |
| APA | Zang, Chongzhi.,Wang, Tao.,Deng, Ke.,Li, Bo.,Hu, Sheng'en.,...&Liu, X. Shirley.(2016).High-dimensional genomic data bias correction and data integration using MANCIE.NATURE COMMUNICATIONS,7,8. |
| MLA | Zang, Chongzhi,et al."High-dimensional genomic data bias correction and data integration using MANCIE".NATURE COMMUNICATIONS 7(2016):8. |
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论