CSpace  > 系统科学研究所
Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks
Wang, Pei1,2; Lu, Jinhu3; Yu, Xinghuo2; Liu, Zengrong4
2015-06-01
Source PublicationIEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
ISSN1932-4545
Volume9Issue:3Pages:312-320
AbstractDuplication and divergence are two basic evolutionary mechanisms of bio-molecular networks. Real-world bio-molecular networks and their statistical characteristics can be well mimicked by artificial algorithms based on the two mechanisms. Bio-molecular networks consist of network motifs, which act as building blocks of large-scale networks. A fundamental question is how network motifs are evolved from long time evolution and natural selection. By considering the effect of various duplication and divergence strategies, we find that the underlying duplication scheme of the real-world undirected bio-molecular networks would rather follow the anti-preference strategy than the random one. The anti-preference duplication mechanism and the dimerization processes can lead to the formation of various motifs, and robustly conserve proper quantities of motifs in the artificial networks as that in the real-world ones. Furthermore, the anti-preference mechanism and edge deletion divergence can robustly preserve the sparsity of the networks. The investigations reveal the possible evolutionary mechanisms of network motifs in real-world bio-molecular networks, and have potential implications in the design, synthesis and reengineering of biological networks for biomedical purpose.
KeywordBio-molecular network duplication and divergence evolutionary mechanism network growth model network motif
DOI10.1109/TBCAS.2014.2343620
Language英语
Funding ProjectNational Science and Technology Major Project of China[2014ZX10004-001-014] ; National Natural Science Foundation of China[61304151] ; National Natural Science Foundation of China[11172158] ; National Natural Science Foundation of China[11472290] ; National Natural Science Foundation of China[61025017] ; Australia ARC[DP130104765] ; Science Foundation of Henan University[2012YBZR007] ; Science Foundation of Henan University[2013YBRW005]
WOS Research AreaEngineering
WOS SubjectEngineering, Biomedical ; Engineering, Electrical & Electronic
WOS IDWOS:000356515100002
PublisherIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/20041
Collection系统科学研究所
Affiliation1.Henan Univ, Sch Math & Informat Sci, Kaifeng 475004, Peoples R China
2.RMIT Univ, Sch Elect & Comp Engn, Melbourne, Vic 3001, Australia
3.Chinese Acad Sci, Acad Math & Syst Sci, Inst Syst Sci, Beijing 100190, Peoples R China
4.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China
Recommended Citation
GB/T 7714
Wang, Pei,Lu, Jinhu,Yu, Xinghuo,et al. Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks[J]. IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS,2015,9(3):312-320.
APA Wang, Pei,Lu, Jinhu,Yu, Xinghuo,&Liu, Zengrong.(2015).Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks.IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS,9(3),312-320.
MLA Wang, Pei,et al."Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks".IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS 9.3(2015):312-320.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Pei]'s Articles
[Lu, Jinhu]'s Articles
[Yu, Xinghuo]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Pei]'s Articles
[Lu, Jinhu]'s Articles
[Yu, Xinghuo]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Pei]'s Articles
[Lu, Jinhu]'s Articles
[Yu, Xinghuo]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.