Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks

doi:10.1109/TBCAS.2014.2343620

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	Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks
	Wang, Pei 1,2; Lu, Jinhu3 ; Yu, Xinghuo 2; Liu, Zengrong 4
	2015-06-01
发表期刊	IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
ISSN	1932-4545
卷号	9 期号:3 页码:312-320
摘要	Duplication and divergence are two basic evolutionary mechanisms of bio-molecular networks. Real-world bio-molecular networks and their statistical characteristics can be well mimicked by artificial algorithms based on the two mechanisms. Bio-molecular networks consist of network motifs, which act as building blocks of large-scale networks. A fundamental question is how network motifs are evolved from long time evolution and natural selection. By considering the effect of various duplication and divergence strategies, we find that the underlying duplication scheme of the real-world undirected bio-molecular networks would rather follow the anti-preference strategy than the random one. The anti-preference duplication mechanism and the dimerization processes can lead to the formation of various motifs, and robustly conserve proper quantities of motifs in the artificial networks as that in the real-world ones. Furthermore, the anti-preference mechanism and edge deletion divergence can robustly preserve the sparsity of the networks. The investigations reveal the possible evolutionary mechanisms of network motifs in real-world bio-molecular networks, and have potential implications in the design, synthesis and reengineering of biological networks for biomedical purpose.
关键词	Bio-molecular network duplication and divergence evolutionary mechanism network growth model network motif
DOI	10.1109/TBCAS.2014.2343620
语种	英语
资助项目	National Science and Technology Major Project of China[2014ZX10004-001-014] ; National Natural Science Foundation of China[61304151] ; National Natural Science Foundation of China[11172158] ; National Natural Science Foundation of China[11472290] ; National Natural Science Foundation of China[61025017] ; Australia ARC[DP130104765] ; Science Foundation of Henan University[2012YBZR007] ; Science Foundation of Henan University[2013YBRW005]
WOS研究方向	Engineering
WOS类目	Engineering, Biomedical ; Engineering, Electrical & Electronic
WOS记录号	WOS:000356515100002
出版者	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/20041
专题	系统科学研究所
通讯作者	Wang, Pei
作者单位	1.Henan Univ, Sch Math & Informat Sci, Kaifeng 475004, Peoples R China 2.RMIT Univ, Sch Elect & Comp Engn, Melbourne, Vic 3001, Australia 3.Chinese Acad Sci, Acad Math & Syst Sci, Inst Syst Sci, Beijing 100190, Peoples R China 4.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China
推荐引用方式 GB/T 7714	Wang, Pei,Lu, Jinhu,Yu, Xinghuo,et al. Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks[J]. IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS,2015,9(3):312-320.
APA	Wang, Pei,Lu, Jinhu,Yu, Xinghuo,&Liu, Zengrong.(2015).Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks.IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS,9(3),312-320.
MLA	Wang, Pei,et al."Duplication and Divergence Effect on Network Motifs in Undirected Bio-Molecular Networks".IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS 9.3(2015):312-320.